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Immortalised murine R349P desmin knock-in myotubes exhibit a reduced proton leak and decreased ADP/ATP translocase levels in purified mitochondria

Effects of Titanium Dioxide Nanoparticles on Cell Growth and Migration of A549 Cells under Simulated Microgravity

Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A

Optical sectioning, or: tackling the background problem

Confocal microscopy offers superior optical sectioning. But what is that exactly? And what about other ways to get rid of the background, such as array-based detectors like the MATRIX?
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Where the tiny becomes mighty: light vs electron microscopy

For centuries, conventional light microscopy was and continues to be the workhorse of labs to visualize cells and cellular details. But the advent of electron microscopy brought about a new level of detail. Let's take a closer look at the two techniques.
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Deep and clear: where confocal beats out wide-field microscopy

Confocal microscopes were designed to get rid of background signal. How do they work? And when do you know it’s time to use one? The answer is in the pinhole.
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How to correct for aberrations in light microscopy

Aberrations can give microscopists a hard time. They belong to microscopy like pathogens belong to life. There are ways to bring diverted rays back on track, but some are better than others. The question is: deformable mirror or correction collar?
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RAYSHAPE – dynamic aberration correction

Ideal imaging conditions are often compromised by imperfections in the optical path. These can severely compromise a microscope’s performance, unless they are eliminated by RAYSHAPE's deformable mirror.
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RAYSHAPE

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Why do superresolution microscopists love alpacas?

Why do superresolution microscopists love alpacas?

It is a very simple yet very important fact: the localization precision of any superresolution microscope can only be as good as the size of the fluorescent staining allows. In other words, when your fluorescent dye is too big or too far away from the protein you want to label, you will never be able to reach a resolution that is higher than this offset. The good news is: there are ways to reduce the offset between target protein and fluorescent label. And one of these are nanobodies.
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Let the cells shine with immunofluorescence labeling

The most versatile and therefore most common strategy to bring the dye to the sample is immunofluorescence. In case you always wanted to know how immunofluorescence works and which properties of antibodies make it so powerful and at the same time define its limits!
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STED and virology

A little insight into the advances in virus research made possible by STED microscopy and a hint to were the journey might go.
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STED-PAINT for high-perfomance superresolution

The combination of STED microscopy and PAINT circumvents the physical limitations of current labeling technology.
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abberior STAR nanobody

SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency

StaR Is a Positive Regulator of Topoisomerase I Activity Involved in Supercoiling Maintenance in Streptococcus pneumoniae

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abberior LIVE special

abberior STAR special

Control of NK cell tolerance in MHC class I-deficiency by regulated SHP-1 localization to the activating immune synapse

Lack of N-glycosylation increases Amyloidogenic processing of the amyloid precursor protein

Differential FSH glycosylation modulates FSHR oligomerization and subsequent cAMP signaling

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control

Bright fluorescent silica-nanoparticle probes for high-resolution STED and confocal microscopy

Pair correlation analysis maps the dynamic two-dimensional organization of natural killer cell receptors at the synapse

Unscrambling fluorophore blinking for comprehensive cluster detection via photoactivated localization microscopy